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If you want to use it, you have to ensure that you have the legal right to do so and that you do not infringe any trademark rights. The study objectives were to compare the effects of the lead nutrient compounds on gut hormone, insulin, and glucose responses to an oral glucose challenge.

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Infusion into the sigmoid colon of 1g L-glutamine in mL saline over 15 minutes caused statistically significant increases, over placebo, in secretion of both GLP-1 and insulin in response to an oral glucose challenge Figure 4. The levels of GLP-1 and insulin secreted in the presence of L-glutamine approached those seen in a typical non-diabetes subject. The hormone responses in the presence of saline control were typical of the impaired responses seen in type 2 diabetes patients. The hormone responses after infusion of butyrate were similar to control responses.

L-glutamine was therefore selected as the lead nutrient compound for further clinical development.

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The effect of infusion of L-glutamine into the sigmoid colon on oral glucose-induced GLP-1 and insulin secretion in type 2 diabetes patients. L-glutamine blue or saline red was infused for 15 minutes shown by the green bar and the glucose challenge was administered at 0 min arrow ; hormones were measured by BioAgilytix using the Meso Scale Discovery assay technology in peripheral blood samples collected over min. The dotted lines show responses from a typical non-diabetic subject for comparison.

Differences between L-glutamine and placebo are statistically different for GLP-1 at 30 min and for insulin at 90 and min.